Summary of - Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy

Document Type

Article

Abstract

Study Background: Coating nanoparticles with natural cell membranes enhances their functionality by combining synthetic properties with biological capabilities like immune evasion and targeted delivery. These biomimetic nanoparticles show great promise in drug delivery, cancer targeting, and imaging. This review explores various types of biomimetic NPs, their fabrication methods, and their biomedical applications while highlighting recent advancements in this innovative field. Research Goals and Hypotheses: The primary goal of this review is to explore the advancements in cell membrane-camouflaged nanoparticles (NPs) as a bioinspired platform for cancer therapy. The hypothesis is that using natural cell membranes to camouflage NPs can enhance their ability to target tumors more effectively, improve immune evasion, and extend circulation time, thereby improving the therapeutic efficacy of cancer treatments. Methodological Approach: The review synthesizes findings from various studies on the development and application of biomimetic NPs in cancer therapy. It details the fabrication techniques, including cell membrane isolation, vesicle preparation, and fusion with NPs, as well as the types of cell membranes used (e.g., erythrocytes, cancer cells, platelets). The review also categorizes different biomimetic NPs based on the type of cell membrane used and discusses their biomedical applications, such as in chemotherapy, immune modulation, and gene therapy. Results and Discoveries: The review highlights that biomimetic NPs, due to their natural cell membrane coating, show improved tumor targeting, prolonged circulation time, and reduced immune clearance compared to conventional NPs. Specific types of cell membranes, such as those from erythrocytes and cancer cells, offer unique advantages like immune evasion and homophilic targeting. The review concludes that while significant progress has been made in developing biomimetic NPs, challenges remain in optimizing their fabrication and application for clinical use.

DOI: https://doi.org/10.1016/j.jconrel.2022.04.019

Publication Date: 2022

Recommended citation: Dhas, N., García, M. C., Kudarha, R., Pandey, A., Nikam, A. N., Gopalan, D., ... & Mutalik, S. (2022). Advancements in cell membrane camouflaged nanoparticles: a bioinspired platform for cancer therapy. Journal of Controlled Release, 346, 71-97.

Publication Date

2022

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