Summary of - Engineered Nano-carrier systems for the oral targeted delivery of follicle stimulating Hormone: Development, characterization, and, assessment of in vitro and in vivo performance and targetability
Document Type
Article
Abstract
Study Background: The study focuses on developing advanced nano-carrier systems for the oral delivery of follicle stimulating hormone (FSH), which is crucial for treating female infertility. Research Goals and Hypotheses: The primary goal was to engineer and optimize nano-carrier systems that enhance the oral bioavailability and targeted delivery of FSH. The hypothesis was that these engineered systems would improve the therapeutic effectiveness of FSH by ensuring targeted delivery to the intended site of action. Methodological Approach: The research involved the development of various nano-carrier formulations, followed by comprehensive characterization techniques to assess their physicochemical properties. In vitro studies were conducted to evaluate the release profiles and cellular uptake of FSH, while in vivo assessments were performed to determine the pharmacokinetics and targetability of the nano-carrier systems. Results and Discoveries: The findings indicated that the engineered nano-carrier systems significantly improved the oral delivery and bioavailability of FSH compared to conventional methods. The study highlights the potential of these nano-carrier systems as a promising approach for enhancing the efficacy of FSH in clinical applications related to female infertility.
DOI: https://doi.org/10.1016/j.ijpharm.2023.122868
Publication Date: 2023
Recommended citation: Raut, S. Y., Fu, K., Taichun, H., Gahane, A., Chaudhari, D., Kushwah, V., ... & Mutalik, S. (2023). Engineered Nano-carrier systems for the oral targeted delivery of follicle stimulating Hormone: Development, characterization, and, assessment of in vitro and in vivo performance and targetability. International journal of pharmaceutics, 637, 122868.
Publication Date
2023
Recommended Citation
Yadaorao Raut, Sushil; Fu, Kengyen; Taichun, Huang; Gahane, Avinash; Chaudhari, Dasharath; Kushwah, Varun; Suresh Managuli, Renuka; Hegde, Aswathi R.; Jain, Sanyog; Kalthur, Guruprasad; Bandu Joshi, Manjunath; Chang, Hsin-I.; Dai, Niann-Tzyy; and Mutalik, Srinivas, "Summary of - Engineered Nano-carrier systems for the oral targeted delivery of follicle stimulating Hormone: Development, characterization, and, assessment of in vitro and in vivo performance and targetability" (2023). Open Access archive. 9417.
https://impressions.manipal.edu/open-access-archive/9417
