Summary of - Comparative role of SOX10 gene in the gliogenesis of central, peripheral, and enteric nervous systems
Document Type
Article
Abstract
The SOX10 gene and its encoded protein, SOX10, play a crucial role in the development of neuroglia from neural crest cells, a process known as gliogenesis. The SOX10 protein binds to DNA at its minor groove via its HMG (High Mobility Group) domain. Upon binding, the protein undergoes conformational changes, leading to DNA bending. This binding subsequently activates several other transcription factors through its transactivation and HMG domains, driving the transformation of neural crest cells into neuroglia. Research indicates that the SOX10 gene is essential for the formation of Schwann cells, oligodendrocytes, and enteric ganglia from neural crest cells. Abnormal expression of this gene can lead to impaired gliogenesis, dysmyelination, and demyelination in the nervous system, as well as intestinal aganglionosis. This review highlights the significant role of the SOX10 gene and protein in the gliogenesis of the enteric nervous system from neural crest cells.
Publication Date
2022
Recommended Citation
Bhattarai, Chacchu; Poudel, Phanindra P.; Ghosh, Arnab; and G Kalthur, Sneha, "Summary of - Comparative role of SOX10 gene in the gliogenesis of central, peripheral, and enteric nervous systems" (2022). Open Access archive. 9469.
https://impressions.manipal.edu/open-access-archive/9469
