Summary of - Cross-talk between AMP-activated protein kinase and the sonic hedgehog pathway in the high-fat diet triggered colorectal cancer
Document Type
Article
Abstract
This is a review article authored by Ms. Beena T B et.al., In abstract, the article describes the crosstalk between AMPK pathway and Shh signalling in highfat diet induced CRC. The primary reason for fatalities linked to colorectal cancer (CRC) is its ability to spread. Signaling pathways significantly influence the onset and advancement of CRC. Emerging research highlights the potential of regulating the sonic hedgehog (Shh) pathway in treating CRC. Additionally, AMPK, a key regulator of metabolism and inflammation, is a promising therapeutic target for this cancer.
A high-fat diet (HFD) is a primary risk factor for developing CRC. Moreover, fats play a crucial role in the abnormal activation of the Shh pathway. This analysis delves into the interconnectedness of HFD consumption, Shh pathway activation, and the progression of CRC. Recent studies suggest that AMPK could be a pivotal regulator capable of managing the complexities of CRC, decreasing lipid levels, and potentially directly suppressing Shh signaling. However, the review also acknowledges potential risks associated with AMPK activation in CRC due to its variable effects. Furthermore, activating AMPK in CRC triggered by HFD might influence cancer progression by controlling both the Shh pathway and metabolic processes.
Publication Date
2023
Recommended Citation
Beena, T B; Jesil, Mathew A; and Harikumar, K.B., "Summary of - Cross-talk between AMP-activated protein kinase and the sonic hedgehog pathway in the high-fat diet triggered colorectal cancer" (2023). Open Access archive. 9473.
https://impressions.manipal.edu/open-access-archive/9473
