Summary of - Hepatorenal Protective role of Red and White Onion in Albino Wistar Rats

Document Type

Article

Abstract

Study Background: The research presented titled “Hepatorenal Protective role of Red and White Onion in Albino Wistar Rats” by Shyamala Nayak , Nayanatara Arun Kumar, Anupama Hegde , Rekha D Kini , Reshma Kumarchandra, Vandana Blossom , Shivanand Pai is focused to analyse the role of red onion and white onion on liver and kidney in Wistar rats

Research Goals and Hypotheses: The phytochemicals present in the red onion and white onion might posses a protective role on kidney and liver

Methodological Approach: Allium cepa Linn (Onion) is a widely used organosulfur dietary compound having profound medicinal benefits. Eighteen Albino Wistar rats weighing 150-200g were divided into three different groups (n=6; n= number of animals in each group). Normal Control (Group I) was administered with 1 ml distilled water. Group II rats were treated with red onion extract (500mg/kg body weight) and the rats belonging to Group III, received white onion extract (500mg/kg body weight). The treatment was given orally once in a day for 30 days. At the end of the 30th day, the animals were anaesthetized, and blood samples were collected through cardiac puncture and were analysed for liver function test and kidney function test. The histological changes in the liver and the kidneys were also observed.

Results and Discoveries:

Total cholesterol (P<0.05), Triglycerides (P<0.001) and Low density lipoproteins (P<0.001) level significantly decreased (P<0.001) in the red onion group compared to the white onion group. Red onion treated groups showed significant reduction (P<0.001) in the level of urea, creatinine and uric acid when compared to white onion treated group. Alkaline phosphate significantly reduced (P<0.001) in red onion treated when compared to white onion treated group.

All the findings were well supported by the histological analysis. In conclusion, our study evaluated the protective effect of red onion and white onion. However, in comparison, red onion treated group showed better protective role when compared to white onion.

Publication Date

November 2023

Recommended Citation

Shyamala Nayak, Nayanatara Arun Kumar, Anupama Hegde, Rekha D Kini, Reshma Kumarchandra, Vandana Blossom, Shivanand Pai. Hepatorenal Protective role of Red and White Onion in Albino Wistar Rats. Research Journal of Pharmacy and Technology. 2023; 16(11):5250-4. doi: 10.52711/0974-360X.2023.00851

Publication Date

2023

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