Summary of Design, Development, and Evaluation of Resveratrol Transdermal Patches for Breast Cancer Therapy

Document Type

Article

Abstract

Study Background: The research titled “Design, development, and evaluation of Resveratrol transdermal patches for breast cancer therapy” by Dr. Usha Y Nayak, Shivaprasad Gadag, Reema Narayan, Yogendra Nayak, Sanjay Garg is centered on developing transdermal patches for resveratrol to enhance its bioavailability and site-specific delivery in breast cancer therapy. It aims to demonstrate improved local drug concentration and therapeutic efficacy compared to oral administration.

Research Goals and Hypotheses: The goal is to develop and evaluate transdermal patches for resveratrol to improve the bioavailability, site-specific delivery, and therapeutic efficacy of breast cancer therapy. Resveratrol transdermal patches with optimized polymers and penetration enhancers will achieve higher local breast tissue concentrations, lower systemic exposure, and greater anti-cancer efficacy compared to oral administration.

Methodological Approach:

  1. Formulation Development and Optimization: Developed resveratrol transdermal patches using hydroxypropyl methylcellulose (HPMC) E15LV, HPMC-K4M, and polyvinyl pyrrolidone (PVP) K30 in the ratio of 3:1:2, incorporating Glycerol-Capryol 90 (4:1) as penetration enhancers and plasticizers, supported by computational screening through quantitative structure-property relationship (QSPR).
  1. In Vivo Evaluation: Applied the optimized resveratrol patches to the breasts of female rats to assess localized delivery, measuring breast tissue disposition and systemic concentration compared to oral resveratrol administration, demonstrated by parameters such as area under the curve (AUC) and mean residence time (MRT).
  1. Therapeutic Efficacy Testing: Evaluated the anti-cancer efficacy of the optimized resveratrol patches in a 7,12-Dimethylbenz[a]anthracene (DMBA)-induced rat mammary cancer model by monitoring tumor volume reduction and serum CA 15-3 levels, comparing the results with those from oral resveratrol administration.

Results and Discoveries:

  1. Enhanced Permeation: The resveratrol transdermal patch with HPMC and PVP polymers, and Glycerol and Capryol 90 enhancers, showed superior permeation and higher breast tissue resveratrol levels compared to oral administration.
  1. Effective Tumor Reduction: In the DMBA-induced rat mammary cancer model, resveratrol patches significantly reduced tumor volume and serum CA 15-3 levels, outperforming oral resveratrol.
  1. Improved Bioavailability: The transdermal patches provided better resveratrol bioavailability and targeted delivery, minimizing systemic exposure and maximizing localized therapeutic effects.

Citation to the base paper: Bathara, M., Date, T., Chaudhari, D., Ghadi, R., Kuche, K., Jain, S., (2020) Exploring the Promising Potential of High Permeation Vesicle-Mediated Localized Transdermal Delivery of Docetaxel in Breast Cancer to Overcome the Limitations of Systemic Chemotherapy. Mol. Pharm. 17, 2473–2486.

Publication Date

2023

Recommended Citation

Gadag, S.; Narayan, R.; Nayak, Y.; Garg, S.; Nayak, U.Y. Design, Development and Evaluation of Resveratrol Transdermal Patches for Breast Cancer Therapy. Int J Pharm 2023, 632, 122558, doi:10.1016/j.ijpharm.2022.122558

Publication Date

2023

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