Summary Of Computational and Experimental Insights in Design and Development of Aceclofenac Co-Crystals

Document Type

Article

Abstract

Study Background: The study titled “Multifunctional engineered mesoporous silica/inorganic material hybrid nanoparticles: Theranostic perspectives” conducted by Dr C H Mehta and Dr. Usha Y Nayak focuses on the design and development of aceclofenac co-crystals, a technique aimed at enhancing the aqueous solubility of drugs by modifying their crystal structure through the incorporation of co-formers. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) known for its poor aqueous solubility, which limits its bioavailability.

Research Goals and Hypotheses: The primary goal is to identify suitable co-formers for aceclofenac co-crystals using computational and experimental methods. The hypothesis is that co-crystallization will improve the solubility and release profile of aceclofenac, thus enhancing its bioavailability.

Methodological Approach:

  1. The study employs a supramolecular synthon approach and computational grid scan methods for co-former selection.
  1. Co-crystals were prepared using solvent evaporation and dry grinding methods. Various co-formers, including oxalic acid, succinic acid, maleic acid, and benzoic acid, were tested.
  1. Characterization techniques included Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), and in vitro drug release studies.

Results and Discoveries:

  1. The findings indicate that maleic acid is the most suitable co-former for aceclofenac, resulting in increased solubility and improved drug release in basic pH conditions.
  1. The solid-state characterization confirmed the formation of co-crystals, with a notable decrease in crystallinity.
  1. Aqueous solubility is increased compared to pure aceclofenac.

Citation to the base paper: Chandel N, Gupta V, Pandey A, Saxena S, Choudhary S. Co-Crystallization of Aceclofenac and Paracetamol and Their Characterization. Int J Pharm Life Sci. 2011; 2(8):1020-1028.

Publication Date

2022

Recommended Citation

Mehta CH, Srinivas PP, Anusha SB, Mahany KBF, Koteshwara KB, Nayak UY. Computational and Experimental Insights in Design and Development of Aceclofenac Co-Crystals. Research J. Pharm. and Tech. 2022; 15(8):3709-3716. DOI: 10.52711/0974-360X.2022.00622

Publication Date

2022

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