Summary of Optimization of Transfersomes Encapsulated with Resveratrol for Targeted Drug Delivery

Document Type

Article

Abstract

Study Background: The research titled “Optimization of Transfersomes Encapsulated with Resveratrol for Targeted Drug Delivery” by Shivaprasad Gadag and Dr. Usha Y Nayak focuses on the development and optimization of transfersomes as a delivery system for Resveratrol (RVT), a compound with potential therapeutic effects in breast cancer treatment.

Research Goals and Hypotheses: The main objective is to develop a robust, efficient transfersome formulation that can enhance the bioavailability and therapeutic efficacy of RVT when delivered transdermally. The hypothesis posits that optimized transfersomes will provide better penetration and sustained release, making them superior to conventional delivery methods.

Methodological Approach:

  1. Formulation Optimization: Using the design of experiments (DOE) methodology, the study explored various factors influencing the formulation, including particle size, polydispersity index (PDI), zeta potential, and entrapment efficiency. The independent variables included the concentration of SPC (soy phosphatidylcholine) and the ratio of SPC to the edge activator (EA).
  2. In vivo Efficacy Testing: The optimized transfersome formulations were tested on breast cancer-induced rats to evaluate their effectiveness in delivering RVT to the targeted tissues.

Results and Discoveries:

  1. Optimization Results: The DOE approach identified the optimal concentrations of SPC and SPC:EA ratio, resulting in transfersomes with desirable size and stability characteristics. The optimized formulation demonstrated high entrapment efficiency and appropriate zeta potential, indicating good stability.
  2. In Vivo Findings: The animal studies showed that the transfersome-based delivery system significantly improved the penetration and bioavailability of RVT. This formulation also provided sustained drug release, enhancing the therapeutic outcomes in the treated rats.

Citation to the base paper:

N. d'Avanzo, G. Torrieri, P. Figueiredo, C. Celia, D. Paolino, A. Correia, K. Moslova, T. Teesalu, M. Fresta, H.A. Santos, LinTT1 peptide-functionalized liposomes for targeted breast cancer therapy, Int. J. Pharm. 597 (2021), 120346, https://doi.org/ 10.1016/J.IJPHARM.2021.120346.

Publication Date

2022

Recommended Citation

Gadag, S., Narayan, R., Sabhahit, J. N., Hari, G., Nayak, Y., Pai, K. S. R., Garg, S., & Nayak, U. Y. (2022). Transpapillary iontophoretic delivery of resveratrol loaded transfersomes for localized delivery to breast cancer. Biomaterials Advances, 140, 213085. https://doi.org/10.1016/j.bioadv.2022.213085

Publication Date

2022

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