Summary of - ameliorative effects of nutritional minerals on lead-induced hematological alterations in male wistar albino rats
Document Type
Article
Abstract
Background: The deficiency of essential minerals increases absorption and thus aggravates the lead-induced toxic effects. This study was aimed at understanding the ameliorative effect of essential minerals on lead-induced alterations in hematological parameters in rats. 320 male Wistar albino rats were grouped into two, with equal numbers. One of the groups of rats was fed on a mineral-supplemented food referred to as a 'well-nourished group' and another group 'undernourished group' on food without mineral supplements. Each group of rats was further subdivided into 'Subjects' and 'Controls.' Subjects of both the groups of rats were exposed to 500 ppm lead acetate up to a period of 300 days (10 months) in drinking water and the role of minerals on lead-induced alterations in hematological parameters was evaluated. A significant decrease (p < 0.001) in hemoglobin (Hb) and δ-aminolevulinic acid dehydratase (δ-ALAD) levels and a significant increase (p < 0.001) in urinary δ-aminolevulinic acid (δ-ALAU) levels were seen in subjects without mineral supplementation compared to those fed on a mineral-enriched diet. A positive correlation was observed between blood lead levels (PbB) and δ-ALAU (r = 0.792) and a negative correlation with Hb (r = -0.926) and δ-ALAD (r = -0.836) in the subjects. These changes were very prominent in the undernourished subjects when compared to the well-nourished subjects. Observations of the present study indicate that mineral supplementation with ongoing lead exposure may help in minimizing the absorption of lead and reduce lead-induced toxic effects.
Citation: Dsouza, H. S., Menezes, G., & Thuppil, V. (2021). Ameliorative effects of nutritional minerals on lead-induced hematological alterations in male Wistar albino rats. Drug and Chemical Toxicology, 45(6), 2483–2487. https://doi.org/10.1080/01480545.2021.1958833
Publication Date
2022
Recommended Citation
Dsouza, Herman Sunil; Menezes, Geraldine; and Thuppil, Venkatesh, "Summary of - ameliorative effects of nutritional minerals on lead-induced hematological alterations in male wistar albino rats" (2022). Open Access archive. 9525.
https://impressions.manipal.edu/open-access-archive/9525
