Summary of - Distinct features of iron based metal organic frameworks (MOFs) for ferroptosis mediated cancer therapy: A comprehensive review

Document Type

Article

Abstract

Study Background: Iron-based metal-organic frameworks (MOFs) have garnered significant attention in cancer therapy due to their unique properties, including high surface area, tunable porosity, and biocompatibility. Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, presents a novel therapeutic strategy for targeting cancer cells. Research Goals and Hypotheses: The primary goal of this comprehensive review is to explore the distinct features of iron-based MOFs and their potential applications in ferroptosis-mediated cancer therapy. The hypothesis suggests that these MOFs can enhance the efficacy of ferroptosis in cancer treatment by improving drug delivery and selectively targeting tumor cells. Methodological Approach: The authors conducted a thorough literature review, analyzing various studies that investigate the synthesis, characterization, and application of iron-based MOFs in cancer therapy. They evaluated the mechanisms by which these frameworks induce ferroptosis and discussed their advantages over traditional therapeutic agents, emphasizing their role in enhancing treatment specificity and reducing side effects.

DOI: https://doi.org/10.1016/j.ccr.2023.215330

Publication Date: 2023

Recommended citation: Kudarha, R., Dhas, N., & Mutalik, S. (2023). Distinct features of iron based metal organic frameworks (MOFs) for ferroptosis mediated cancer therapy: A comprehensive review. Coordination Chemistry Reviews, 494, 215330.

Publication Date

2023

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