Summary of - Dopaminergic Signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition

Document Type

Article

Abstract

The review titled “Dopaminergic signaling as a Plausible Modulator of Astrocytic Toll-Like Receptor 4: A Crosstalk between Neuroinflammation and Cognition” discusses the role of neuroinflammation in the development of AD. Even though microglia are activated during inflammation, significantly less is explained regarding the role of astrocytes in neuroinflammation. In the astrocytes, reactive astrocytes, particularly A1 astrocytes, are implicated in neuroinflammation, whereas A2 astrocytes exhibit neuroprotective effects. The cognitive effects of dopamine in the context of neuroinflammation have also been discussed. Recently, researchers have discovered the importance of Toll-Like Receptor 4 in modulating neuroinflammation. Thus, we decided to conduct a review focused on a specific neuroglia, astrocytes, stimulating the receptor Toll-Like Receptor 4 and how they interact with Dopaminergic signaling, contributing to neuroinflammation and cognition.

First Page-539

Last Page- 557

DOI- 10.2174/1871527321666220413090541

Publication Year- 2023

Citation to the base paper:

Balistreri, C. R., & Monastero, R. (2023). Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?. Brain sciences, 14(1), 19.

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Recommended Citation

Gurram, P. C., Manandhar, S., Satarker, S., Mudgal, J., Arora, D., & Nampoothiri, M. (2023). Dopaminergic signaling as a plausible modulator of astrocytic toll-like receptor 4: a crosstalk between neuroinflammation and cognition. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 22(4), 539-557.

Publication Date

2023

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