Summary of - Preparation and Evaluation of In-house Fabricated Floating Tablets of Black Pepper Extract

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Article

Abstract

Study background: The research presented titled “Preparation and Evaluation of In-house Fabricated Floating Tablets of Black Pepper Extract” by Saipriya Shettigar, Usha Y. Nayak, Mahalaxmi Rathnanand, Venkatesh Kamath B., Chandrashekar K. S., Vasudev Pai, Aswatha Ram H.N. is to prepare and evaluate the floating tablets of black pepper extract as pepper is known to have antioxidant, antiulcer activity and gastro protective effects. Research goals and Hypotheses: The primary goal was to design the development as well as evaluation of Pepper extract floating tablets for the management of peptic ulcers due by H. pylori. Methodological Approach: We have developed gastro-retentive floating tablets of standardized pepper extract. Directly compressed were subjected to evaluation for various in vitro parameters. Floating tablets containing ingredients viz Pepper extract, HPMC K100M hydrophilic polymer, colophony as hydrophobic polymer were used. Sodium bicarbonate was used to generate gas. Lubricants such as Talc and Magnesium stearate were used and to improve compressibility, Lactose was utilized. Directly compressed tablets were then subjected to evaluation. Formulations were optimized based on buoyancy time and considering drug release in vitro.

Cite: Shettigar, S., Nayak, U.Y., Rathnanand, M., Kamath, V.B., Chandrashekar, K.S., Pai, V. and Ram, A.H., 2023. Preparation and evaluation of in-house fabricated floating tablets of black pepper extract. Research Journal of Pharmacy and Technology, 16(8), pp.3733-3738.

Publication Date

2023

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