Summary of - Involvement of Terminase Complex in Herpes Simplex Virus Mature Virion Egress

Document Type

Article

Abstract

The life cycle of the Herpes simplex virus starts with attachment to the host cell, injection of the nucleocapsid into the cytoplasm, replication, transcription, and viral protein production, and finally the assembly of the mature virion nucleocapsid. The assembled nucleocapsid exits the host nucleus and gains a tegument layer bound within a membrane phospholipid bilayer. The packaged virion particle then exits the host cell. The interaction of the (Deoxyribonucleic acid) DNA packaging complex- terminate, present on the mature viral nucleocapsid, with other proteins involved in nuclear egress and cytoplasmic tegumentation has led to the proposal of the model by which the terminase complex may be involved in these two events. The role of terminase complex in Herpes Simplex Virus (HSV) genomic DNA encapsidation into the capsid is previously established. Still, the role of the terminase subunits post DNA packaging remains unclear. The current review provides a model by which the terminase complex may have a role to play in the events of nuclear egress and secondary envelopment.

DOI

https://doi.org/10.2174/1389203723666220217144432

Publication date

February 1, 2022

Recommended citation

Rao, A.M., Balireddy, S., Mohammad, F.S., Somashekara, D.M. and Hariharapura, R.C., 2022. Involvement of Terminase Complex in Herpes Simplex Virus Mature Virion Egress. Current Protein and Peptide Science, 23(2), pp.105-113.

Publication Date

2022

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