Summary of - Development and Pharmacological assessment of dehydrozingerone gel formulation on imiquimod-induced psoriasis in mice

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Article

Abstract

BPharm Group Project Spotlight: Psoriasis Treatment through Collaborative Research

We are excited to highlight a remarkable group project led by BPharm students at the Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education. This project, titled "Development and Pharmacological Assessment of Dehydrozingerone Gel Formulation on Imiquimod-Induced Psoriasis in Mice," showcases the power of collaboration and innovation in scientific research.

Project Team:

  • BPharm Students: Anusha Prabhu, Chaitanyamayee Kalakota, Jeslin Johnson, Kufaila Mansoor
  • Ph.D. Mentor: Gangadhar Hari
  • Teacher Mentors: Rekha R Shenoy, Karkala Sreedhara Ranganath Pai, Krishnadas Nandakumar

Published In: Research Journal of Pharmacy and Technology, Volume 15, Issue 10, 2022 DOI: 10.52711/0974-360X.2022.00749

Abstract: Psoriasis is a challenging chronic inflammatory autoimmune skin disorder influenced by genetic, environmental, and immune factors. This project focuses on dehydrozingerone (DHZ), a structural half-analogue of curcumin known for its antioxidant, antibacterial, and anti-inflammatory properties. The research explores DHZ's potential to block TNF-alpha, a cytokine implicated in psoriasis. Using an imiquimod-induced psoriasis model in mice, the team demonstrated that DHZ significantly reduces scaling, suggesting its promise as an effective treatment option.

Under the guidance of Ph.D. student Gangadhar Hari and teacher mentors Rekha R Shenoy, Karkala Sreedhara Ranganath Pai, and Krishnadas Nandakumar, the BPharm students worked collaboratively, enhancing their team-building skills and gaining invaluable research experience. This project is a classic example of how a young workforce can embark on a fruitful academic journey when adequately nurtured and mentored. It contributes to our understanding of potential psoriasis treatments and highlights the importance of mentorship and teamwork in scientific endeavors.

Congratulations to the entire team for their dedication and for making a meaningful impact in the field of pharmaceutical sciences.

For more details, read the full article:

RJPT - (rjptonline.org)

How to cite this article: Gangadhar Hari, Anusha Prabhu, Chaitanyamayee Kalakota, Jeslin Johnson, Kufaila Mansoor, Rekha R Shenoy, Karkala Sreedhara Ranganath Pai, Krishnadas Nandakumar. Development and Pharmacological assessment of dehydrozingerone gel formulation on imiquimod-induced psoriasis in mice. Research Journal of Pharmacy and Technology2022; 15(10):4469-2. doi: 10.52711/0974-360X.2022.00749

Keywords: Dehydrozingerone, Psoriasis, Imiquimod, TNF-alpha, Autoimmune

Publication Date

2022

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