Document Type

Article

Publication Title

International Journal of Current Research and Review

Abstract

Introduction: Glyoxalase-1, an erythrocyte enzyme of the glyoxalase system catabolizes the methylglyoxal is the main precur-sor of advanced glycation end products (AGEs). Elevated methylglyoxal and AGEs are strongly associated with the development of diabetic complications. The association between trace elements and glyoxalase-1 in diabetic patients is not well established. Objective: To assess the concentration of serum Mg, Se, and Mn in diabetic patients and compare these in different groups defined in terms of duration of the DM. Methods: The present study compares the concentration of micronutrients (magnesium, selenium, and manganese) in non-complicated (group A ≤4 years) and complicated (group B >4years) diabetes mellitus type-2 patients. Sixty-four (50.8%) patients were in group A, and 62 (49.2%) patients in group B. This cross-sectional study also correlates the concentrations with glyoxa-lase-1 levels. Results: Glyoxalase-1 has shown higher concentration in group B than A (50.65±5.32 vs. 41.29±3.58 ng/mL; p-value <0.001) where all the micronutrients have shown higher levels in group A. One-way ANOVA test showed a significant association between glyoxalase-1 and glycosylated Haemoglobin, magnesium, and selenium (p<0.05). Conclusion: Glyoxalase-1 is a predictor of poor glycemic control in diabetic patients, and it is associated with the early development of a diabetic complication. The concentrations of serum magnesium, selenium, and manganese decrease with the increased duration of diabetes.

First Page

166

Last Page

172

DOI

10.31782/IJCRR.2020.122432

Publication Date

12-1-2020

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