Treatment with Tinospora cordifolia ameliorates prenatal stress and maternal separation-induced memory deficits by restoring amygdaloid neuronal architecture
Document Type
Article
Publication Title
Journal of HerbMed Pharmacology
Abstract
Introduction: Tinospora cordifolia (TC) possesses antioxidative properties and has been shown to improve cognition. In this study, the effects of TC were investigated on prenatal vibratory stress, maternal separation-induced amygdala plasticity, and memory retention in pregnant rats and their neonates. Methods: Four experimental animal groups of pregnant Wistar rats were employed in this research, including normal & vehicle controls, the stressed group, which received 3 hours of vibratory stress/day, and the TC-treated group, which received 6 mg/kg TC before vibratory stress. The neonates born to these mothers were then subjected to maternal separation, followed by postnatal TC treatment. After 6 weeks, the animals were assessed to evaluate memory retention, serum cortisol levels, and neuronal structural changes in the amygdala. Results: Neonates exposed to prenatal vibratory stress and maternal separation entered the dark compartment more quickly during the retention test (P<0.001), indicating reduced memory retention. In contrast, the TC-treated groups showed longer latencies (P<0.001), suggesting improved memory retention. The TC-treated mothers and neonates had longer dendrites with more branching points and intersections (P<0.001). However, these dendrites underwent pruning, indicating a complex structural response to stress and TC treatment. Conclusion: The results indicate that TC exerts neuroprotective effects against prenatal vibratory stress and maternal separation and aids memory retrieval in rats by restoring amygdala neuronal damage.
First Page
606
Last Page
619
DOI
10.34172/jhp.2024.51517
Publication Date
10-1-2024
Recommended Citation
Ashwini, L. S.; Rao, Mohandas K.G.; Rai, Kiranmai S.; and Shetty, Somashekar B., "Treatment with Tinospora cordifolia ameliorates prenatal stress and maternal separation-induced memory deficits by restoring amygdaloid neuronal architecture" (2024). Open Access archive. 9969.
https://impressions.manipal.edu/open-access-archive/9969
