Response to Ovulation Induction in Women with Different Polycystic Ovarian Phenotypes

Document Type

Article

Publication Title

International Journal of Infertility and Fetal Medicine

Abstract

Introduction: One of the most prevalent endocrinopathies in women of reproductive age is polycystic ovarian syndrome (PCOS). Ovulation induction and fertility treatment are necessary in PCOS-affected women. Aim: To study the growth of the dominant follicle and document ovulation in different phenotypic groups of PCOS after the use of ovulation induction drugs. Settings and design: The study was conducted in a tertiary hospital after Institutional Ethics Committee (IEC) approval: 857–2020. Materials and methods: All enrolled women were subjected to detailed history and examination, and relevant findings were noted. Transvaginal sonography (TVS) was done to identify PCOS patterns. Based on the different phenotypes (A, B, C, D) and symptoms, ovulation induction agents like clomiphene citrate, letrozole, or human menopausal gonadotropin (HMG) were started. They were followed to assess the ovulation response as no, normal, or hyper-response. Statistical analysis used: Data were coded and recorded in a Microsoft Excel spreadsheet program. Statistical Package for the Social Sciences (SPSS) v23 (IBM Corp.) was used for data analysis. Results: In this study, out of 95 patients, 3.2% of the participants had phenotype A, 1.1% had B, and 5.3% had C. A total of 90.5% of the participants had phenotype D. All (100.0%) participants in phenotype A had hyperandrogenism. Phenotype A also had a high mean follicle-stimulating hormone (FSH) (7.20 IU/L) value compared to other phenotypes, and the response was better in groups without hyperandrogenism, as understood by a significant p-value < 0.05 in different phenotypes obtained in this study. Conclusion: Phenotype D was more prevalent among all phenotypes. The risk of OHSS was higher for phenotype A. Normal response was better in phenotype D, which does not have hyperandrogenism. Elevating letrozole doses showed a similar effect in all PCOS phenotypes, improving ovulation rates without significant difference. Estimation of hyperandrogenism is important in the prognostication of ovulation induction in different phenotypes.

First Page

93

Last Page

97

DOI

10.5005/jp-journals-10016-1383

Publication Date

1-1-2025

This document is currently not available here.

Share

COinS