Alpha-glucosidase inhibition and antioxidant activity of Ensete superbum (Roxb.) Cheesman seeds: GC-MS-based profiling of the active metabolites and molecular docking study

Document Type

Article

Publication Title

Current Science

Abstract

The present study aims to uncover the alpha-gluco-sidase inhibition (AGI) and antioxidant activities of Ensete superbum seed extract. The AGI activity of crude extract (IC50 = 0.17 μg/ml) and silica gel column purified fraction (ESSFR4; IC50 = 0.02 μg/ml) was excellent when compared to acarbose (IC50 = 1720 μg/ ml). Also, the free-radical scavenging ability of ESSFR4 was comparable to ascorbic acid. Among the five compounds identified from ESSFR4, pentasiloxane, dodecamethyl and 2,4-hexadienedioic acid, bis(tri-methylsilyl) ester, had the best binding affinities against human and yeast AG enzymes respectively. However, ADME/toxicity evaluation of these five compounds revealed that they would require further structural scrutiny and in vivo studies before recom-mending them as an alternative to the present AGIs to treat type-2 diabetes.

First Page

682

Last Page

688

DOI

10.18520/cs/v122/i6/682-688

Publication Date

3-25-2022

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