Summary of Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives

Document Type

Article

Abstract

Study Background

The review article titled “Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives” by Dr. Usha Y Nayak, Bhavana B Bhat, Chetan H Mehta, Akhil Suresh, and Varalakshmi Velagacherlaexplains the current scenarios and prospects of controlled drug release technologies for chronotherapy. Circadian rhythms are 24-hour cycles in the body synchronized with external factors, and their disruption is linked to lifestyle diseases. Chronotherapeutics aims to optimize drug efficacy and minimize toxicity by aligning treatments with these biological cycles.

Research Goals and Hypotheses

The study aims to explore how circadian rhythm disruptions cause diseases and to evaluate the efficacy of chronotherapeutic approaches like controlled drug release. It hypothesizes that treating diseases in sync with circadian rhythms will enhance therapeutic outcomes and reduce side effects.

Methodological Approach

  1. A comprehensive review is presented linking circadian rhythm disruptions to various diseases and the impact of chronotherapy.
  2. The effectiveness of controlled drug release technologies in delivering treatments at specific circadian phases in animal models and clinical trials is studied.
  3. Treatment outcomes were analyzed focusing on drug efficacy and toxicity levels about the timing of administration within the circadian cycle.

Results and Discoveries

  1. Disease Link: Confirmed that circadian rhythm disruptions are significantly associated with various lifestyle diseases.
  2. Chronotherapy Efficacy: Demonstrated that drugs administered according to circadian rhythms showed improved efficacy and reduced toxicity.
  3. Controlled Release Benefits: Found that controlled drug release technologies effectively align treatment with circadian cycles, offering better management of disease symptoms and overall health outcomes.

Citation to the base paper: Ortiz-Tudela E, Mteyrek A, Ballesta A, Innominato PF, Lévi F. Cancer chronotherapeutics: Experimental, theoretical, and clinical aspects. Handb Exp Pharmacol 2013; 217(217): 261-88.

Publication Date

2023

Recommended Citation

Bhat, B.B.; Mehta, C.H.; Suresh, A.; Velagacherla, V.; Nayak, U.Y. Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives. Curr Pharm Des 2023, 29, 1069–1091, doi:10.2174/1381612829666230423144232.

Publication Date

2023

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