Summary of Multifunctional Engineered Mesoporous Silica/Inorganic Material Hybrid Nanoparticles: Theranostic Perspectives
Document Type
Article
Abstract
Study Background: The study titled “Multifunctional engineered mesoporous silica/inorganic material hybrid nanoparticles: Theranostic perspectives” conducted by Neha B Fernades and Dr. Usha Y Nayak explores Mesoporous silica nanoparticles (MSNs)t that are promising inorganic nanocarrier for developing theranostic platforms due to their unique properties like large surface area, tunable pore size, high drug loading capacity, and good biocompatibility. Combining MSNs with upconversion nanoparticles (UCNPs) that can convert near-infrared light into UV/visible light enables NIR-triggered drug release and imaging.
Research Goals and Hypotheses: The review aims to provide an overview of the recent developments in multifunctional engineered MSN/inorganic material hybrid nanoparticles for Theranostic applications, focusing on their synthesis, properties, and biomedical applications.
Methodological Approach:
- The review discusses the properties of MSNs and UCNPs that make them suitable for Theranostic applications.
- It covers different approaches to incorporating imaging agents into MSNs and the challenges and limitations of MSN hybrid nanoparticles.
Results and Discoveries:
- MSNs can be engineered to have the desired pore size, surface area, and functionality for targeted drug delivery and imaging.
- Combining MSNs with UCNPs enables NIR-triggered drug release and deep tissue imaging.
- Several studies have explored MSN-based Theranostic nanoconjugates for cancer treatment.
Citation to the base paper: S. Senapati, A.K. Mahanta, S. Kumar, P. Maiti, Controlled drug delivery vehicles for cancer treatment and their performance, Sig Transduct Target Ther. 3 (2018) 1–19, https://doi.org/10.1038/s41392-017-0004-3
Publication Date
2023
Recommended Citation
Fernandes, N.B., Nayak, Y., Garg, S., & Nayak, U.Y. (2023). Multifunctional engineered mesoporous silica/inorganic material hybrid nanoparticles: Theranostic perspectives. Coordination Chemistry Reviews, 478, 214977. https://doi.org/10.1016/j.ccr.2022.214977
Publication Date
2023
Recommended Citation
Nayak, Usha Y; Fernandes, N B; Nayak, Yogendra; and Garg, S, "Summary of Multifunctional Engineered Mesoporous Silica/Inorganic Material Hybrid Nanoparticles: Theranostic Perspectives" (2023). Open Access archive. 9497.
https://impressions.manipal.edu/open-access-archive/9497
