Summary of - Medium and large scale preparation of Nanostructured Lipid Carriers of asenapine maleate: Quality-by-design based optimization, production, characterization and performance evaluation

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Article

Abstract

Study Background: The study titled focuses on developing nanostructured lipid carriers (NLCs) for asenapine maleate, an antipsychotic drug. The research employs a quality-by-design (QbD) approach to enhance drug delivery and therapeutic efficacy. Research Goals and Hypotheses: The primary goal was to optimize the formulation and production processes of NLCs at both medium and large scales. The hypothesis posited that systematic optimization of formulation variables would lead to improved drug loading, stability, and brain delivery of asenapine maleate. Methodological Approach: The study utilized high-pressure homogenization for NLC production, scaling from 100 mL to 1000 mL batches. Key formulation variables were optimized using the QbD framework, and comprehensive characterization techniques assessed particle size, zeta potential, entrapment efficiency, and in vitro drug release profiles. Results and Discoveries: The findings indicated that the optimized NLCs exhibited favorable physicochemical properties and significantly enhanced brain delivery and therapeutic outcomes of asenapine maleate compared to conventional formulations. This underscores the potential of NLCs as an effective drug delivery system in neuropharmacology.

DOI: 10.1016/j.jddst.2022.103275

Publication Date: 2022

Recommended citation: Rao, R. R., Pisay, M., Kumar, S., Kulkarni, S., Pandey, A., Kulkarni, V. I., & Mutalik, S. (2022). Medium and large scale preparation of Nanostructured Lipid Carriers of asenapine maleate: Quality-by-design based optimization, production, characterization and performance evaluation. Journal of Drug Delivery Science and Technology, 71, 103275.

Publication Date

2022

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